Molecular physiology of the thiazide-sensitive sodium–chloride cotransporter
نویسندگان
چکیده
منابع مشابه
A kinetic model of the thiazide-sensitive Na-Cl cotransporter.
The aim of this study was to construct a numerical model of the thiazide-sensitive Na-Cl cotransporter (TSC) that can predict kinetics of thiazide binding and substrate transport of TSC. We hypothesized that the mechanisms underlying these kinetic properties can be approximated by a state diagram in which the transporter has two binding sites, one for sodium and another for chloride and thiazid...
متن کاملγ-Adducin stimulates the thiazide-sensitive NaCl cotransporter.
The thiazide-sensitive NaCl cotransporter (NCC) plays a key role in renal salt reabsorption and the determination of systemic BP, but the molecular mechanisms governing the regulation of NCC are not completely understood. Here, through pull-down experiments coupled to mass spectrometry, we found that γ-adducin interacts with the NCC transporter. γ-Adducin colocalized with NCC to the distal conv...
متن کاملThe Thiazide - sensitive Na + : Cl - Cotransporter : molecular biology , 3 functional properties , and regulation by WNKs
13 Address correspondence to: 14 Gerardo Gamba, M.D., Ph.D. 15 Vasco de Quiroga No. 15, Tlalpan 14000 Mexico City, Mexico 16 e-mail: [email protected] or [email protected] 17 18
متن کاملThe thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs.
The thiazide-sensitive Na+-Cl(-) cotransporter is the major salt reabsorption pathway in the distal convoluted tubule, which is located just after the macula densa at the beginning of the aldosterone-sensitive nephron. This cotransporter was identified at the molecular level in the early 1990s by the pioneering work of Steven C. Hebert and coworkers, opening the molecular area, not only for the...
متن کاملThe structural unit of the thiazide-sensitive NaCl cotransporter is a homodimer.
The thiazide-sensitive NaCl cotransporter (NCC) is responsible for the reabsorption of 5% of the filtered load of NaCl in the kidney. Mutations in NCC cause Gitelman syndrome. To gain insight into its regulation, detailed information on the structural composition of its functional unit is essential. Western blot analysis of total membranes of Xenopus laevis oocytes heterologously expressing FLA...
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ژورنال
عنوان ژورنال: Current Opinion in Nephrology and Hypertension
سال: 2009
ISSN: 1062-4821
DOI: 10.1097/mnh.0b013e32832f2fcb